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研究活動


平成21年度


本学グローバルCOEプログラム事業推進担当者による成果(発表論文)をご紹介します。

平成21年度

M.-R. Ahn, K. Kunimasa, S. Kumazawa, T. Nakayama, K. Kaji, Y. Uto, H. Hori, H. Nagasawa, T. Ohta: Correlation between antiangiogenic activity and antioxidant activity of various components from propolis. Mol. Nutr. Food Res. 53, 643-651, 2009

Y. Aihara, A. Yoshida, T. Furuta, T. Wakimoto, T. Akizawa, M. Konishi, T. Kan: Regioselective Synthesis of Methylated Epigallocatechin Gallate via Nitrobenzenesulfonyl (Ns) Protecting Group. Bioorg. Med. Chem. Lett. 19, 4171-4174, 2009

M.-J. Bae, T. Ishii, K. Minoda, Y. Kawada, T. Ichikawa, T. Mori, M. Kamihira, T. Nakayama: Albumin stabilizes (−)-epigallocatechin gallate in human serum: binding capacity and antioxidant property. Mol. Nutr. Food Res. 53 709-715, 2009

N. Fukaya, K. Mochizuki, Y. Tanaka, T. Kumazawa, Z. Jiuxin, M. Fuchigami, T. Goda: The alpha-glucosidase inhibitor miglitol delays the development of diabetes and dysfunctional insulin secretion in pancreatic beta-cells in OLETF rats. Eur. J. Pharmacol. 624, 51-57, 2009

N. Fukaya, K. Mochizuki, M. Shimada, T. Goda: The α-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of inflammatory cytokines induced by hyperglycemia in peripheral leukocytes. Nutr. 25, 657-667, 2009

T. Furuta, H. Onuki, M. Mochizuki, M. Ito, M. Inai, T. Wakimoto, T. Kan: Solid Support Synthesis of Artificial Phospholipids. Synlett 3373-3377, 2009

T. Furuta, M. Nakayama, H. Suzuki, H. Tajimi, M. Inai, H. Nukaya, T. Wakimoto, T. Kan: Concise Synthesis of Chafurosides A and B. Org. Lett. 11. 2233-2236, 2009

J. Hanato, K. Kuriyama, T. Mizumoto, K. Debari, J. Hatanaka, S. Onoue, S. Yamada: Liposomal formulations of glucagon-like peptide-1: Improved bioavailability and anti-diabetic effect. Int. J. Pharm. 382, 111-116, 2009

K. Hatanaka, T. Asai, H. Koide, E. Kenjo, T. Tsuzuku, N. Harada, H. Tsukada, N. Oku: Development of Double-Stranded siRNA Labeling Method Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography. Bioconjugate Chem. in press

T. Hibino, M. Yuzurihara, Y. Kasa, A. Takeda: Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic and Serotonergic Receptors. J. Pharmacol. Sci. 111, 73-81, 2009

K. I.P.J. Hidari, M. Ogata, T. Murata, S. Shimada, W. Kozaki, E. Y. Park, T. Suzuki, T. Usui: Chemoenzymatic synthesis of sialoglycopolypeptides as glycomimetics to block infection by avian and human influenza viruses. Bioconjugate Chem. 20, 538–549, 2009

K. I.P.J. Hidari, K. Oyama, G. Ito, M. Nakayama, M. Inai, S. Goto, Y. Kanai, K. Watanabe, K. Yoshida, T. Furuta, T. Kan, T. Suzuki: Identification and characterization of flavonoids as sialyltransferase inhibitors. Biochem. Biophys. Res. Commun. 382, 609-613, 2009

T. Hosaka, M. Sekimoto, K. Nemoto, M. Degawa: Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine. Cancer Sci. 101, 652-657, 2010

Y. Hoshino, T. Urakami, T. Kodama, H. Koide, N. Oku, Y. Okahata, K.-J. Shea: Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide. Small 5, 1562-1568, 2009

A. Ikari , A. Sanada , C. Okude, H. Sawada , Y. Yamazaki , J. Sugatani, M. Miwa: Up-regularion of TRPM6 transcriptional activity by AP-1 in renal epithelial cells. J. Cell. Physiol. 222(3), 481-487, 2010

A. Ikari , K. Kinjo , K. Atomi, Y. Sasaki, Y. Yamazaki, J. Sugatani: Extracellular Mg (2+) regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation. Biochim. Biophys. Acta 1798 (3), 415-421, 2010

A. Ikari, K. Atomi, A. Takiguchi, Y. Yamazaki, M. Miwa, J. Sugatani: Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cells. Biochem. Biophys. Res. Commun. 384(3), 306-310, 2009

N. Ikegaya, T. Yoshida, T. Kohsaka, A. Suzuki, N. Kobayashi, T. Yamamoto, Y. Fujigaki, A. Hishida, H. Kumagai: Effects of relaxin on development of mesangial proliferative nephritis. Ann. N. Y. Acad. Sci. 1160, 300-303, 2009

Y. Inamochi, K. Mochizuki, A. Osaki, T. Ishii, T. Nakayama, T. Goda: Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression. Biochem. Biophys. Res. Commun. 392, 16-21, 2010

T. Ishii, K. Minoda, M.-J. Bae, T. Mori, Y. Uekusa, T. Ichikawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama: Binding affinity of tea catechins for human serum albumin: Characterization by high-performance affinity chromatography with immobilized albumin column. Mol. Nutr. Food Res. in press

T. Ishii, M. Wakabayashi, T. Mori, T. Nakayama: A new method for the detection and characterization of α-lipoic acid mixed disulphides. Free Radical Res. 44, 403-409, 2010

T. Ishii, T. Asai, T. Urakami, N. Oku: Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion. Brain Res. 1321, 164-168, 2010

Y. Ito, L. Oyunzul, M. Seki, T. Oki-Fujino, M. Matsui, S. Yamada: Quantitative analysis of the loss of muscarinic receptors in various peripheral tissues in M1-M5 single subtype knockout mice. Br. J. Pharmacol. 156, 1147-1153, 2009

Y. Iwasaki, M. Tanabe, Y. Kayama, M. Abe, M. Kashio, K. Koizumi, Y. Okumura, Y. Morimitsu, M. Tominaga, Y. Ozawa, T. Watanabe: Miogadial and miogatrial with a,b-unsaturated 1,4-dialdehyde moieties—Novel and potent TRPA1 agonists. Life Sci. 85, 60-69, 2009

I. Iwashina, K. Mochizuki, Y. Inamochi, T. Goda: Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions. J. Nutr. Biochem. in press

H. Kameji, K. Mochizuki, N. Miyoshi, T. Goda: Beta-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of ROS generation and the suppression of genes related to insulin sensitivity induced by TNF-α. Nutr. in press

M. Kashiwamura, K. Kurohane, T. Tanikawa, A. Deguchi, D. Miyamoto, Y. Imai: Shiga toxin kills epithelial cells isolated from distal but not proximal part of mouse colon. Biol. Pharm. Bull. 32, 1614–1617, 2009

Y. Katanasaka, T. Ishii, T. Asai, H. Naitou, N. Maeda, F. Koizumi, S. Miyagawa, N. Ohashi, N. Oku: Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78. Int. J. Cancer in press

Y. Kato, K. Haraguchi, M. Kubota, M. Seto, T.Okura, S. Ikushiro, N. Koga, S. Yamada, M. Degawa: A possible mechanism for the decrease in serum thyroxine level by a TCDD-like PCB congener, 3,3',4,4',5-pentachlorobiphenyl, in mice. Drug Metab. Dispos. 38(1), 150-156, 2010

M. Kato, N. Shoda, T. Yamamoto, R. Shiratori, T. Toyo'oka: Development of a silica-based double-network hydrogel for high-throughput screening of encapsulated enzymes. Analyst 134, 577-581, 2009

M. Kato, T. Yamamoto, M. Sekimoto, M. Degawa, T. Toyo'oka: An easy cell-based microchip assay method for a CYP1A1-mediated drug metabolism using adhesive HepG2 cells. J. Appl. Phys. 105, 1-4, 2009

M. Kato, Y. Onda, M. Sekimoto, M. Degawa, T. Toyo'oka: A capillary electrochromatography-electron spray ionization-mass spectrometry method for simultaneous analysis of charged and neutral constituents of a hepatocarcinoma cell metabolome. J. Chromatogr. A 1216, 8277-8282, 2009

Y. Kobayashi, H. Kako, H. Yokogoshi: Contribution of intracellular Ca2+ concentration and protein dephosphorylation to the induction of dopamine release from PC12 cells by the green odor compound hexanal. Cell. Mol. Neurobiol. accepted for publication, 2010

H. Koide, T. Asai, K. Hatanaka, S. Akai, T. Ishii, E. Kenjo, T. Ishida, H. Kiwada, H. Tsukada, N. Oku: T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes. Int. J. Pharm. in press

K. Kunimasa, M.-R. Ahn, T. Kobayashi, R. Eguchi, S. Kumazawa, Y. Fujimori, T. Nakano, T. Nakayama, K. Kaji, T. Ohta: Brazilian propolis suppresses angiogenesis by inducing apoptosis in tube-forming endothelial cells through inactivation of survival signal ERK1/2. Evid.-based Complement Altern. Med. in press

S. Kurosawa, S. Uchida Y. Ito, S. Yamada: Effect of ursodeoxycholic acid on the pharmacokinetics and midazolam and CYP3A activity in the liver and small intestine of rats. Xenobiotica 39, 162-170, 2009

P. Luecha, K. Umehara, T. Miyase, H. Noguchi: Antiestrogenic Constituents of the Thai Medicinal Plants Capparis flavicans and Vitex glabrata. J. Nat. Prod. 72(11), 1954–1959, 2009

T. Matsuda, K. Kurohane, Y. Imai: Di-(2-ethylhexyl) phthalate enhances skin sensitization to isocyanate haptens in mice. Toxicol. Lett. 192, 97–100, 2010

S. Misaka, H. Sato, Y. Yamauchi, S. Onoue, S. Yamada: Novel dry powder formulation of Ovalbumin for development of COPD-like animal model: physicochemical characterization and biomarker profiling in rats. Eur. J. Pharm. Sci. 37, 469-476, 2009

Y. Misaki, R. Miyauchi, K. Mochizuki, S. Takabe, M. Shimada, Y. Ichikawa, T. Goda: Plasma IL-1b concentrations are closely associated with fasting blood glucose levels in healthy and preclinical middle-aged, non-overweight and overweight Japanese men. Metab. in press

Y, Mizuuchi, S.-P. Shi, K. Wanibuchi, A. Kojima, H. Morita, H. Noguchi, I. Abe: Novel type III polyketide synthases from Aloe arborescens. FEBS J. 276, 2391–2401, 2009

K. Mochizuki, K. Honma, M. Shimada, T. Goda: The regulation of jejunal induction of the maltase-glucoamylase gene by a high-starch/ low-fat diet in mice. Mol. Nutr. Food Res. 54, 1-7, 2010

K. Mochizuki, E. Hanai, K. Suruga, S. Kuranuki, T. Goda: Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the α-glucosidase inhibitor miglitol. Metab. in press

K. Mochizuki, M. Igawa-Tada, S. Takase, T. Goda: Feeding rats a high fat/carbohydrate ratio diet reduces jejunal S/I activity ratio and unsialylated galactose on glycosylated chain of S-I complex. Life Sci. 86, 524-531, 2010

H. Morita, Y. Shimokawa, M. Tanio, R. Kato, H. Noguchi, S. Sugio, I. Abe: A structure-based mechanism for benzalacetone synthase from Rheum palmatum. Proc. Natl. Acad. Sci. U.S.A. 107(2), 669-73, 2010

K. Motoyama, Y. Nakai, T. Miyashita, Y. Fukui, M. Morita, K. Sanmiya, H. Sakakibara, I. Matsumoto, K. Abe, T. Yagabe, N. Yajima, K. Shimoi: Isolation stress for 30 days alters hepatic gene expression profiles, especially with reference to lipid metabolism in mice. Physiol. Genomics 37(2), 79-87, 2009

Y. Murase, T. Asai, Y. Katanasaka, T. Sugiyama, K. Shimizu, N. Maeda, N. Oku: A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy. Cancer Lett. 287, 165-171, 2010

Y. Murayama, K. Mochizuki, M. Shimada, Y. Matsuoka, K. Shibata, T. Goda: Effects of wheat albumin consumption on expression of genes related to lipogenesis and insulin sensitivity in adipose tissues of rats. J. Agric. Food Chem. 57, 1606-1611, 2009

Y. Murayama, K. Mochizuki, M. Shimada, S. Fujimoto, K. Nukui, K. Shibata, T. Goda: Dietary supplementation with a-amylase inhibitor wheat albumin to high-fat diet-induced insulin-resistant rats is associated with increased expression of genes related to fatty acid synthesis in adipose tissue. J. Agric. Food Chem. 57, 9332-9338, 2009

M. Ogata, K. I. P. J. Hidari, W. Kozaki, T. Murata, J. Hiratake, E. Y. Park, T. Suzuki, T. Usui: Molecular Design of Spacer-N-Linked Sialoglycopolypeptide as Polymeric Inhibitors Against Influenza Virus Infection. Biomacromolecules 10, 1894-1903, 2009

H. Oka, T. Onaga, T. Koyama, C.-T. Guo, Y. Suzuki, Y. Esumi, K. Hatano, D. Terunuma, K. Matsuoka: Syntheses and biological evaluations of carbosilane dendrimers uniformly functionalized with sialyl α2→3) lactose moieties as inhibitors for human influenza viruses. Bioorg. Med. Chem. 17, 5465-5475, 2009

S. Onoue, H. Sato, Y. Kawabata, T. Mizumoto, N. Hashimoto, S. Yamada: In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy. J. Controlled Release 138, 16-23, 2009

M. Osabe, J. Sugatani, A. Takemura, M. Kurosawa, Y. Yamazaki, A. Ikari, M. Miwa: Up-regulation of CAR expression through Elk-1 in HepG2 and SW480 cells by serum starvation stress. FEBS Lett. 583(5), 885-889, 2009

Y. Osada, R. Miyauchi, T. Goda, N. Kasezawa, H. Horiike, M. Iida, S. Sasaki, K. Yamakawa-Kobayashi: Variations in the WNK1 gene modulates the effect of dietary intake of sodium and potassium on blood pressure determination. J. Hum. Genet. 54, 474-478, 2009

Y. Sakai, K. Ikeuchi, Y. Yamada, T. Wakimoto, T. Kan: Modified Julia-Kocienski Reaction Promoted by Means of m-NPT (Nitrophenyltetrazole) sulfone. Synlett 827-829, 2010

H. Sakakibara, T. Ogawa, A. Koyabagi, S. Kobayashi, T. Goda, S. Kumazawa, H. Kobayashi, K. Shimoi: Distribution and excretion of bilberry anthocyanines. J. Agric. Food Chem. 57(17), 7681-7686, 2009

J. Sakamoto, T. Koyama, D. Miyamoto, S. Yingsakmongkon, K. I.P.J. Hidari, W. Jampangern, T. Suzuki, Y. Suzuki, Y. Esumi, T. Nakamura, K. Hatano, D. Terunuma, K. Matsuoka: Systematic syntheses of influenza neuraminidase inhibitors: A series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties. Bioorg. Med. Chem. 17, 5451-5464, 2009

N. Sakurai, K. Mochizuki, H. Kameji, M. Shimada, T. Goda: (-)-Epigallocatechin gallate enhances the expression of gene related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation. Nutr. 25, 1047-1056, 2009

Y. Seto, S. Onoue, S. Yamada: In vitro/In vivo phototoxic risk assessments of griseofulvin Based on photobiochemical and disposition behaviors. Eur. J. Pharm. Sci. 38, 104-111, 2009

S.-P. Shi, K. Wanibuchi, H. Morita, K. Endo, H. Noguchi, I. Abe: Enzymatic formation of unnatural novel chalcone, stilbene, and benzophenone scaffolds by plant type III polyketide synthase. Org. Lett. 10, 551–554, 2009

S.-P. Shi, H. Morita, K. Wanibuchi, H. Noguchi, I. Abe: Enzymatic formation of unnatural novel polyketide scaffolds by plant-specific type III polyketide synthase. Tetrahedron Lett. 50, 2150–2153, 2009

M. Shimada, K. Mochizuki, T. Goda: Feeding rats dietary resistant starch shifts the peak of SGLT1 gene expression and histone H3 acetylation on the gene from the upper jejunum towards the ileum. J. Agric. Food Chem. 57, 8049-8055, 2009

M. Shimizu, H. Kato, T. Ogawa, A. Kurachi, Y. Nakagawa, H. Kobayashi: Sigma factor phosphorylation in the photosynthetic control of photosystem stoichiometry. Proc. Natl. Acad. Sci. U.S.A. 107, in press

K. Shimizu, M. Osada, K. Takemoto, Y. Yamamoto, T. Asai, N. Oku: Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane. J. Controlled Release 141, 208-215, 2010

K. Shimizu, N.K. Shimizu, W. Hakamata, K. Unno, T. Asai, N. Oku: Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice. Biol. Pharm. Bull. 33,117-121, 2010

N. Sriwilaijaroen, P. Wilairat, H. Hiramatsu, T. Takahashi, T. Suzuki, M. Ito, Y. Ito, M. Tashiro, Y. Suzuki: Mechanisms of the action of povidone-iodine against human and avian influenza A viruses: its effects on hemagglutination and sialidase activities. Virol. J. 06, 124, 2009

J. Sugatani, M. Osabe, M. Kurosawa, N. Kitamura, A. Ikari, M. Miwa: Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2 activity: Cell-cycle dependent expression. Drug Metab. Dispos. 38(1), 177-186, 2010

S. W. Suh, S. J. Won, A. M. Hamby, Y. Fan, C. T. Sheline, H. Tamano, A. Takeda, J. Liu: Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J. Cereb. Blood Flow Metab. 29, 1579-1588, 2009

K. Suzuki, J. Sakamoto, T. Koyama, S. Yingsakmongkon, Y. Suzuki, K. Hatano, D. Terunuma, K. Matsuoka: Synthesis of sialic acid derivatives having a C=C double bond substituted at the C-5 position and their glycopolymers. Bioorg. Biomed. Chem. Lett. 19, 5105-5108, 2009

T. Suzuki, K. Mochizuki, T. Goda: Localized expression of genes related to carbohydrate and lipid absorption along the crypt-villus axis of rat jejunum. Biochim. Biophys. Acta 1790, 1624-1635, 2009

H. Takahama, T. Minamino, H. Asanuma, M. Fujita, T. Asai, M. Wakeno, H. Sasaki, H. Kikuchi, K. Hashimoto, N. Oku, M. Asakura, J. Kim, S. Takashima, K. Komamura, M. Sugimachi, N. Mochizuki, M. Kitakaze: Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats. J. Am. Coll. Cardiol. 53, 709-717, 2009

T. Takahashi, A. Hashimoto, M. Maruyama, H. Ishida, M. Kiso, Y. Kawaoka, Y. Suzuki, T. Suzuki: Identification of amino acid residues of influenza A virus H3 HA contributing to the recognition of molecular species of sialic acid. FEBS Lett. 583, 3171-3174, 2009

A. Takeda, H. Iwaki, M. Ando, K. Itagaki, M. Suzuki, N. Oku: Zinc Differentially Acts on Components of Long-term Potentiation at Hippocampal CA1 Synapse. Brain Res. in press

A. Takeda, H. Itoh, A. Nagayoshi, N. Oku: Abnormal calcium mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet. Epilepsy Res. 83, 73-80, 2009

A. Takeda, M. Ando, S. Kanno, N. Oku: Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation. Neurotoxicol. 30, 712-717, 2009

A. Takeda, N. Sakurada, M. Ando, S. Kanno, N. Oku: Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus. Neurochem. Int. 55, 376-382, 2009

A. Takeda, S. Fuke, M. Ando, N. Oku: Positive Modulation of Long-term Potentiation at Hippocampal CA1 Synapses by Low Micromolar Concentrations of Zinc. Neurosci. 158, 585-591, 2009

Y. Taki, Y. Yamazaki, F. Shimura, S. Yamada, K. Umegaki: Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats. J. Pharmacol. Sci. 109, 459-462, 2009

H. Tamano, F. Kan, M. Kawamura, N. Oku, A. Takeda: Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation. Neurochem. Int. 55, 536-541, 2009

Y. Tanaka, K. Mochizuki, N. Fukaya, M. Shimada, T. Goda: The α-glucosidase inhibitor miglitol suppresses postprandial hyperglycemia and IL-1β and TNF-α gene expression induced in rat peripheral leukocytes by intermittent sucrose loading. Br. J. Nutr. 102, 221-225, 2009

Y. Tanaka, M. Hosokawa, K. Otsu, T. Watanabe, S. Yazawa: Assessment of capsiconinoid composition, nonpungent capsaicinoid analogues, in Capsicum cultivars. J. Agric. Food Chem. 57, 5407-5412, 2009

Y. Tobisawa, Y. Imai, M. Fukuda, H. Kawashima: Sulfation of colonic mucins by N-acetylglucosamine-6-O-sulfotransferase-2 and its protective function in experimental colitis in mice. J. Biol. Chem. 285(9). 6750-6760, 2010

S. Tomono, N. Miyoshi, K. Sato, Y. Ohba, H. Ohshima: Formation of cholesterol ozonolysis products through an ozone-free mechanism mediated by the myeloperoxidase-H2O2-chloride system. Biochem. Biophys. Res. Commun. 383(2), 222-227, 2009

K. Umehara, K. Nemoto, A. Matsushita, E. Terada, O. Monthakantirat, W. De-Eknamkul, T. Miyase, T. Warashina, M. Degawa, H. Noguchi: Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parWiflora and their effects on estrogenic-responsive human breast cancer cells. J. Nat. Prod. 72, 2163-2168, 2009

T. Urakami, K. Sakai, T. Asai, D. Fukumoto, H. Tsukada, N. Oku: Evaluation of O-[(18)F]fluoromethyl-D-tyrosine as a radiotracer for tumor imaging with positron emission tomography. Nucl. Med. Biol. 36, 295-303, 2009

T. Urakami, T. Kawaguchi, S. Akai, K. Hatanaka, H. Koide, K. Shimizu, T. Asai, D. Fukumoto, N. Harada, H. Tsukada, N. Oku: In vivo distribution of liposome-encapsulated hemoglobin determined by positron emission tomography. Artif. Organs. 33, 164-168, 2009

T. Wakimoto, M. Nitta, K. Kasahara, T. Chiba, Y. Ye, K. Tsuji, T. Kan, H. Nukaya, M. Ishiguro, M. Koike, Y. Yokoo, Y. Suwa: Structure-activity relationship study on a 1 adrenergic receptor antagonists from beer. Bioorg. Med. Chem. Lett. 19, 5905-5908, 2009

M. Watanabe, H. Tamano, T. Kikuchi, A. Takeda: Susceptibility to Stress in Young Rats after 2-week Zinc Deprivation. Neurochem. Int. 56, 410-416, 2010

Wuritu, Y. Ozawa, Gaowa, F. Kawamori, T. Masuda, T. Masuzawa, H. Fujita, N. Ohashi: Structural analysis of a p44/msp2 expression site of Anaplasma phagocytophilum in naturally infected ticks in Japan. J. Med. Microbiol. 58, 1638-1644, 2009

S. Yamada, C. Takeuchi, L. Oyunzul, Y. Ito: Bladder angiotensin-II receptors: Characterization and alteration in bladder outlet obstruction. Eur. Urol. 55, 482-489, 2009

T. Yamada, T. Terashima, R. Kawano, R. Furuno, T. Okubo, L. R. Juneja, H. Yokogoshi: Theanine, γ-glutamylethylamide, a unique amino acid in tea leaves, modulates neurotransmitter concentrations in the brain striatum interstitium in conscious rats. Amino Acids 36(1), 21-27, 2009

T. Yamada, Y. Yamada, Y. Okano, T. Terashima, H. Yokogoshi: Anxiolytic effects of short- and long-term administration of cacao mass on rat elevated T-maze test. J. Nutr. Biochem. 20, 948-955, 2009

N. Yamaguchi, S. Miyamoto, Y. Ogura, T. Goda, K. Suruga: Hepatocyte nuclear factor-4alpha regulates human cellular retinol-binding protein type II gene expression in intestinal cells. Am. J. Physiol. Gastrointest. Liver Physiol. 296, 524-533, 2009

T. Yamauchi, Y. Johzuka-Hisatomi, S. Fukada-Tanaka, R. Terada, I. Nakamura, S. Iida: Homologous recombination-mediated knock-in targeting of the MET1a gene for maintenance DNA methyltransferase reproducibly reveals dosage-dependent spatiotemporal gene expression in rice. Plant J. 60, 386-396, 2009

K. Yasui, H. Tanabe, N. Okada, R. Fukutomi, Y. Ishigami, M. Isemura: Effects of chronic ingestion of catechin-rich green tea on hepatic gene expression of gluconeogenic enzymes in rats. Biomed. Res. in press

S. Yokoshima, Y. Abe, N. Watanabe, Y. Kita, T. Kan, T. Iwatsubo, T. Tomita, T. Fukuyama: Development of Photoaffinity Probes for -Secretase Equipped with a Nitrobenzenesulfonamide-type Cleavable Linker. Bioorg. Med. Chem. Lett. 20, 1798-1799, 2010

A. Yokoyama, H. Sakakibara, A. Crozier, Y. Kawai, A. Matsui, J. Terao, S. Kumazawa, K. Shimoi: Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats. Free Radical Res. 43(10), 913-921, 2009

N. Yoshimura, M. Nakayama: Nominative case marking and verb inflection in L2 grammar: Evidence from Japanese college students’ composition. In Otsu, Yukio (ed.) The Proceedings of the 2009 Tokyo Conference on Psycholinguistics 359-383. Tokyo: Hituzi Syobo, 2009

N. Yoshimura, M. Nakayama: Acquisition of two types of -s by Japanese EFL Learners: The role of L1 transfer. In Y-S. Yang, S-W. Tang, C. Kim, J-Y. Yoon, Y-S. Kang, K-A. Kim, H. Yoo, Y. Jang, and H-K. Kang (eds.), Current Issues in Linguistic Interfaces 2. 253-263. Seoul, Korea: Hankook Munhwasa. 2009

藤野知美, 伊藤由彦, 瀧優子, 柿澤希実, 尾上誠良, 今井康之, 奥直人, 野口博司, 伊藤邦彦, 小林裕和, 大橋典男, 合田敏尚, 木苗直秀, 梅垣敬三, 渡邉裕司, 山田静雄: WarfarinとビタミンKの相互作用に関する文献的研究.臨床薬理, 41, 43-52, 2010