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研究活動


平成22年度


本学グローバルCOEプログラム事業推進担当者による成果(発表論文)をご紹介します。

平成22年度

Y. Ohmichi, J. Hirakawa, Y. Imai, M. Fukuda, H. Kawashima: Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses. J. Exp. Med., 208(5), 1015-1025 (2011)

T. Wakimoto, T. Asakawa, S. Akahoshi, T, Suzuki, K. Nagai, H. Kawagishi, T. Kan: Proof the existence of an unstable amino acid, pleurocybellaziridine, in Pleurocybella porrigens (angel’s wing mushroom). Angew. Chem. Int. Ed., 50, 1168-1170 (2011)

M. Shimizu, H. Kato, T. Ogawa, A. Kurachi, Y. Nakagawa, and H. Kobayashi: Sigma factor phosphorylation in the photosynthetic control of photosystem stoichiometry. Proc. Natl. Acad. Sci. USA, 107, 10760-10764 (2010)

Y. Hoshino, H. Koide, T. Urakami, H. Kanazawa, T. Kodama, N. Oku, Shea KJ: Recognition, neutralization, and clearance of target peptides in the bloodstream of living mice by molecularly imprinted polymer nanoparticles: a plastic antibody. J. Am. Chem. Soc., 132, 6644-6645 (2010)

C. A. Nidom, R. Takano, S. Yamada, Y. Sakai-Tagawa, S. Daulay, D. Aswadi, T. Suzuki, Y. Suzuki, K. Shinya, K. Iwatsuki-Horimoto, Y. Muramoto, Y. Kawaoka: Influenza A (H5N1) viruses from pigs, Indonesia. Emerg. Infect. Dis. 16, 1515-1523 (2010)

N. Miyoshi, T. Nagasawa, R. Mabuchi, Y. Yasui, K. Wakabayashi, T. Tanaka, Ohshima H: Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin. Cancer Prev. Res., (2011) in press

K. Shimizu, M. Osada, K. Takemoto, Y. Yamamoto, T. Asai, N. Oku: Temperature-dependent transfer of amphotericin B from liposomal membrane of AmBisome to fungal cell membrane. J. Control. Release, 141, 208-215 (2010)

A. Yoshida, Y. Hirooka, Y. Sugata, M. Nitta, T. Manabe, S. Ido, K. Murakami, R. K. Saha, T. Suzuki, M. Ohshima, A. Yoshida, K. Itoh, K. Shimizu, N. Oku, T. Furuta, T. Asakawa, T. Wakimoto, T. Kan: Concise synthesis of catechin probes enabling analysis and imaging of EGCg. Chem Commun, 47, 1794-1796 (2011)

T. Asakawa, A. Hiza, M. Nakayama, M. Inai, D. Oyama, H. Koide, K. Shimizu, T. Wakimoto, N. Harada, H. Tsukada, N. Oku, T. Kan: PET Imaging of Nobiletin Based on a Practical Total Synthesis. Chem Commun, 47, 2868 – 2870 (2011)

T. Higashi, Y. Isobe, H. Ouchi, H. Suzuki, Y. Okazaki, T. Asakawa, T. Furuta, T. Wakimoto, T. Kan: Stereocntrolled Synthesis of (+)-Methoxyphenylkainic acid and (+)-Phenylkainic acid. Org. Lett., 13, 1089-1091 (2011)

J. Hirakawa, K. Tsuboi, K. Sato, M. Kobayashi, S. Watanabe, A. Takakura, Y. Imai, Y. Ito, M. Fukuda, H. Kawashima: Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycan in lymphocyte homing. J. Biol. Chem., 285, 40864-40878 (2010)

Y. Tobisawa, Y. Imai, M. Fukuda, H. Kawashima: Sulfation of colonic mucins by N-acetylglucosamine-6-O-sulfotransferase-2 and its protective function in experimental colitis in mice. J. Biol. Chem., 285, 6750–6760 (2010)

T. Suzuki, V. Douard, K. Mochizuki, T. Goda, R. Ferraris: Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter GLUT5 during development of rat small intestine. Biochem. J., 435, 43-53 (2011)

K. Koyama, A. Ito, J. Yamamoto, T. Nishio, J. Kajikuri, Y. Dohi, N. Ohte, A. Sano, H. Nakamura, H. Kumagai, T. Itoh: Randomized controlled trial of the effect of short-term coadministration of methylcobalamin and folate on serum ADMA concentration in patients receiving long-term hemodialysis. Am J Kidney Dis. 55, 1069-1078 (2010)

H. Tsutsui, T. Maeda, T. Toyo'oka, J.Z. Min, S. Inagaki, T. Higashi, Y. Kagawa: Practical analytical approach for the identification of biomarker candidates in prediabetic state based upon metabonomic study by ultra-performance liquid chromatography coupled to electrospray ionization time-of-flight mass spectrometry. J. Proteome Res., 9, 3912-3922 (2010)

S. Tomono, N. Miyoshi, H. Shiokawa, T. Iwabuchi, Y. Aratani, T. Higashi, H. Nukaya, H. Ohshima: Formation of cholesterol ozonolysis products in vitro and in vivo through a myeloperoxidase-dependent pathway, J. Lipid. Res., 52(1): 87-97 (2011)

M. Watanabe, T. Hirokawa, T. Kobayashi, A. Yoshida, Y. Ito, S. Yamada, N. Orimoto, Y. Yamasaki, M. Arisawa, S. Shuto: Investigation of the bioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy. J. Med. Chem., 53: 3585-3593 (2010)

K. Kawai, K. Kaku, N. Izawa, M. Shimizu, H. Kobayashi, and T. Shimizu: Transformation of Arabidopsis by mutated acetolactate synthase genes from rice and Arabidopsis that confer specific resistance to pyrimidinylcarboxylate-type ALS inhibitors. Plant Biotech., 27, 75-84 (2010)

Y. Katanasaka, T. Ishii, T. Asai, H. Naitou, N. Maeda, F. Koizumi, S. Miyagawa, N. Ohashi, N. Oku: Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78. Int. J. Cancer 127, 2685-2698 (2010)

A. Ikari, A. Sanada, C. Okude, H. Sawada, Y. Yamazaki, J. Sugatani, M. Miwa: Up-regulation of TRPM6 transcriptional activity by AP-1 in renal epithelial cells. J Cell Physiol. 222, 481-487 (2010)

A. Ikari, A. Takiguchi, K. Atomi, T. Sato, J. Sugatani: Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cells. J Cell Physiol, in press

M. Sakaguchi, T. Ohura, T. Iwata, S Takahashi, S. Akai, T. Kan, H. Murai, M. Fujiwara, O. Watanabe, M. Narita: Diblock Copolymer of Bacterial Cellulose and Poly(methyl methacrylate) Initiated by Chain-End-Type Radicals Produced by Mechanical Scission of Glycosidic Linkages of Bacterial Cellulose. Biomacromolecules ACS, 11, 3059-3066 (2010)

T. Ishii, K. Minoda, M.-J. Bae, T. Mori, Y. Uekusa, T. Ichikawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama: Binding affinity of tea catechins for HSA: Characterization by high-performance affinity chromatography with immobilized albumin column. Mol. Nutr. Food Res., 54, 816-822 (2010)

K. Mochizuki, K. Honma, M. Shimada, T. Goda: The regulation of jejunal induction of the maltase-glucoamylase gene by a high-starch/ low-fat diet in mice. Mol. Nutr. Food Res., 54, 1445-1451 (2010)

N. Sriwilaijaroen, S. Kondo, H. Yagi, N. Takemae, T. Saito, H. Hiramatsu, K. Kato, Y. Suzuki: N-glycans from porcine trachea and lung: Predominant NeuAcα2-6Gal could be a selective pressure for influenza variants in favor of human-type receptor. PLoS ONE, 6, issue 2, e-16302 (2011)

T. Hayashi, M. Nakamichi, H. Naitou, N. Ohashi, Y. Imai, M. Miyake: Proteomic analysis of growth phase-dependent expression of Legionella pneumophila proteins which involves regulation of bacterial virulence traits. PLoS One, 5, e11718 (2010)

T. Hayashi, M. Nakamichi, H. Naitou, N. Ohashi, Y. Imai, M. Miyake: Proteomic analysis of growth phase-dependent expression of Legionella pneumophila proteins for identifying novel virulence-associated factors. PLoS One 22, e11718 (2010)

T. Takahashi, Y. Kurebayashi, K. Ikeya, T. Mizuno, K. Fukushima, H. Kawamoto, Y. Kawaoka, Y. Suzuki, T. Suzuki: The Low-pH Stability Discovered in Neuraminidase of 1918 Pandemic Influenza A Virus Enhances Virus Replication. PLoS One 5 (12), e15556 (2010)

N. Miyoshi, Y. Wakao, S. Tomono, M. Tatemichi, T. Yan, H. Ohshima: The enhancement of the oral bioavailability of γ-tocotorienol in mice by γ-cyclodextrin inclusion. J. Nutr. Biochem. (2011) in press

T. Dewa, T. Asai, Y. Tsunoda, K. Kato, D. Baba, M. Uchida, A. Sumino, K. Niwata, T. Umemoto, K. Iida, N. Oku, M. Nango: Liposomal polyamine-dialkyl phosphate conjugates as effective gene carriers: Chemical structure, morphology, and gene transfer activity. Bioconjugate Chem. 21, 844-852 (2010)

I. Iwashina, K. Mochizuki, Y. Inamochi, T. Goda: Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions. J. Nutr. Biochem., 22, 334-343 (2011)

T. Furuta, J. Yamamoto, Y. Kitamura, A. Hashimoto, H. Masu, I. Azumaya, T. Kan, T. Kawabata: Synthesis of Axially Chiral Amino Acid and Amino Alcohols via Additive-Ligand-Free Pd-Catalyzed Domino Coupling Reaction and Subsequent Transformations of the Product Amidoaza[5]helicene. J. Org. Chem., 75, 7010-7013, (2010)

T. Itoh, H. Takemura, K. Shimoi, K. Yamamoto K: A 3D model of CYP1B1 explains the Dominant 4-hydroxylation of estradiol, J. Chem. Inf. Model, 50(6), 1173-1178 (2010)

T. Hosaka, M. Sekimoto, K. Nemoto, M. Degawa: Augmentation of 3-methylcholanthrene-induced bioactivation in the human hepatoma cell line HepG2 by the calcium channel blocker nicardipine. Cancer Sci.,101, 652-657 (2010)

S. Yamada, Y. Ito, Y. Taki, M. Seki, M. Nanri, F. Yamashita, K. Morishima, I. Komoto, K. Yoshida: The N-oxide metabolite contributes to bladder selectivity resulting from oral propiverine: muscarinic receptor binding and pharmacokinetics. Drug Metab. Dis.. 38: 1314-1321 (2010)

J. Sugatani, M. Osabe, M. Kurosawa, N. Kitamura, A. Ikari, M. Miwa: Induction of UGT1A1 and CYP2B6 by an antimitogenic factor in HepG2 cells is mediated through suppression of cyclin-dependent kinase 2. Drug Metab. Dispos. 38, 177-186 (2010)

J. Sugatani, S. Sadamitsu, M. Kurosawa, S. Ikushiro, T. Sakaki, A. Ikari, M. Miwa: Nutritional status affects fluvastatin-induced hepatotoxicity and myopathy in rats. Drug Metab. Dispos. 38, 1655-1664 (2010)

Y. Kato, K. Haraguchi, M. Kubota, Y. Seto, T. Okura, S. Ikushiro, N. Koga, S. Yamada, M. Degawa: A possible mechanism for the decrease in serum thyroxine level by a 2,3,7,8-tetrachlorodibenzo- p-dioxin-like polychlorinated biphenyl congener, 3,3',4,4',5-pentachlorobiphenyl in mice. Drug Metab. Dispos., 38, 150-156 (2010)

Y. Kato, K. Haraguchi, Y. Ito, A. Fujii, T. Yamazaki, T. Endo, N. Koga, S.Yamada, M. Degawa: Polychlorinated biphenyl-mediated decrease in serum thyroxine level in rodents. Drug Metab. Dispos., 38, 697-704 (2010)

Y. Murase, T. Asai, Y. Katanasaka, T. Sugiyama, K. Shimizu, N. Maeda, N. Oku: A novel DDS strategy, “dual-targeting”, and its application for antineovascular therapy. Cancer Lett., 287, 165-171 (2010)

D. Kato, S. Era, I. Watanabe, Ma. Arihara, N. Sugiura, K. Kimata, Y. Suzuki, K. Morita, K. I.P.J. Hidari, T. Suzuki: Antiviral activity of chondroitin sulphate E targeting dengue virus envelope protein. Antiviral Res. 88, 236-243 (2010)

R. K. Saha, T. Takahashi, Y. Kurebayashi, K. Fukushima, A. Minami, N. Kinbara, M. Ichitani, Y. M. Sagesaka, T. Suzuki: Antiviral effect of strictinin on influenza virus replication. Antiviral Res. 88, 10-18 (2010)

A. Ikari , K. Kinjo , K. Atomi, Y. Sasaki, Y. Yamazaki, J. Sugatani: Extracellular Mg (2+) regulates the tight junctional localization of claudin-16 mediated by ERK-dependent phosphorylation. Biochim Biophys Acta 1798 (3), 415-421 (2010)

M. Ando, N. Oku, A. Takeda: Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin. Neurochem. Int., 57, 608-614 (2010)

M. Watanabe, H. Tamano, T. Kikuchi, A. Takeda: Susceptibility to stress in young rats after 2-week zinc deprivation. Neurochem. Int., 56, 410-416 (2010)

T. Matsuda, K. Kurohane, Y. Imai: Di-(2-ethylhexyl) phthalate enhances skin sensitization to isocyanate haptens in mice. Toxicol. Lett., 192, 97–100 (2010)

M. Hiroi, Y. Nagahara, R. Miyauchi, Y. Misaki, T. Goda, N. Kasezawa, S. Sasaki, K. Yamakawa-Kobayashi: The Combination of Genetic Variations in the PRDX3 Gene and Dietary Fat Intake Contribute to Obesity Risk. Obesity (Dec 2. 2010, Epub ahead of print)

Y. Kato, H. Suzuki, K. Haraguchi, S. Ikushiro, Y. Ito, S. Uchida, S. Yamada, M. Degawa: A possible mechanism for the decrease in serum thyroxine level by phenobarbital in rodents. Toxicol. Appl. Pharmacol., 249, 238-246 (2010)

A. Takeda, H. Tamano, S. Imano, N. Oku: Increases in extracellular zinc in the amygdala in acquisition and recall of fear experience and their roles in response to fear. Neuroscience, 168, 715-722 (2010)

A. Takeda, S. Takada, M. Ando, K. Itagaki, H. Tamano, M. Suzuki, H. Iwaki, N, Oku: Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol. Neuroscience, 171, 443-450 (2010)

D. A. Boltz, B. Douangngeun, P. Phommachanh, S. Sinthasak, R. Mondry, C. Obert, P. Seiler, R. Keating, Y. Suzuki, H. Hiramatsu, E. A. Govorkova, R. G. Webster: Emergence of H5N1 Avian Influenza Viruses with Reduced Sensitivity to Neuraminidase Inhibitors and Novel Reassortants in LAO PDR. J. Gen Virol., 91, 949-959 (2010)

N. Takemae, R. Ruttanapumma, S. Parchariyanon, S. Yoneyama, T. Hayashi, H. Hiramatsu, N. Sriwilaijaroen, Y. Uchida, S. Kondo, H. Yagi, K. Kato, Y. Suzuki, T. Saito: Alterations in receptor binding properties of swine influenza viruses of H1 subtype after isolation in embryonated chicken eggs. J. Gen. Virol., 91, 938-948 (2010)

K. Tomiyama, H. Nakashima, Y. Arakawa, H. Kumagai: Mechanism underlying the olfactory disturbance induced by an intraperitoneal injection of tributyltin chloride in rats. Toxicology. 276, 110-114 (2010)

H. Takemura, H. Nagayoshi, T. Matsuda, H. Sakakibara, M. Morita, A. Matsui, T. Ohura, K. Shimoi: Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells, Toxicol., 274(1-3), 42-48. (2010)

H. Sakakibara,CPN. Romanowski, V. Jakubcakova, C. Flachskamm, K. Shimoi, M. Kimura: Feeble awake effects of plasminogen activator inhibitor type-1 in mice. Behav. Brain Res., in press.

N. Sriwilaijaroen, A. Kadowaki, Y. Onishi, N. Gato, M. Ujike, T. Odagiri, M. Tashiro, Y. Suzuki: Mumefural and related HMF derivatives from Japanese apricot fruit juice concentrate show multiple inhibitory effects on pandemic influenza A (H1N1) virus. Food Chem., 127, 1-9 (2011)

M. Saito, E. Kazuyama, S. Shimizu, F. Dimitriadis, Y. Kinoshita, E. Masuda, S. Yamada, K. Satoh: Muscarinic receptors and their mRNAs in type 2 Goto-Kakizaki diabetic rat prostate. Prostate, 70: 1533-1539 (2010)

T. Watanabe, K. Ohnuki, K. Kobata: Studies on the metabolism and toxicology of emerging capsinoids. Expert Opinion Drug Metab. Toxicol. (2011) in press

R. Saito, S. Ohkawa, S. Ichinose, M. Nishikino, N. Ikegaya, H. Kumagai: Validity of mid-arm muscular area measured by anthropometry in nonobese patients with increased muscle atrophy and variation of subcutaneous fat thickness. Eur J Clin Nutr. 64, 899-904 (2010)

J. Hatanaka, H. Chikamori, H. Sato, S. Uchida, K. Debari, S. Onoue, S. Yamada: Physicochemical and pharmacological characterization of α-tocopherol loaded nano-emulsion system. Int. J. Pharm., 396: 188-193 (2010)

S. Onoue, H. Takahashi, Y. Kawabata, Y. Seto, J. Hatanaka, B.N. Timmermann, S. Yamada: Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. J. Pharm. Sci., 99: 1871-1881 (2010)

M. Kojima, M. Sekimoto, M. Degawa: Androgen-mediated down-regulation of CYP1A subfamily genes in the pig liver. J. Endocrinol., 207, 203-211 (2010)

T. Ishii, T. Mori, T. Ichikawa, M. Kaku, K. Kusaka, Y. Uekusa, M. Akagawa, Y. Aihara, T. Furuta, T. Wakimoto, T. Kan, T. Nakayama: Structural characteristics of green tea catechins for formation of protein carbonyl in human serum albumin. Bioorg. Med. Chem., 18, 4892-4896, (2010)

H. Takemura, T. Itoh, K. Yamamoto, H. Sakakibara, K. Shimoi: Selective inhibition of methoxyflavonoids on human CYP1B1 activity, Bioorg. Med. Chem., 18(17), 6310-6315 (2010)

Y. Sakai, K. Ikeuchi, Y. Yamada, T. Wakimoto, T. Kan: Modified Julia-Kocienski Reaction Promoted by Means of m-NPT (Nitrophenyltetrazole) sulfone. SYNLETT, 827-827 (2010)

S. Ieda, T. Kan, T. Fukuyama: Synthesis of the Optically Active Key Intermediate of FR901483. Tetrahedron Letters 51, 4027-4029, (2010)

H. Takemura, H. Uchiyama, T. Ohura, H. Sakakibara, R. Kuruto, T. Amagai, K. Shimoi: A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells, J. Steroid Biochem. Mol. Biol., 118(1-2), 70-76 (2010)

H. Kameji, K. Mochizuki, N. Miyoshi, T. Goda: β-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of ROS generation and the suppression of genes related to insulin sensitivity induced by TNF-α. Nutrition, 26, 1151-1156 (2010)

K. Mochizuki, E. Hanai, K. Suruga, S. Kuranuki, T. Goda: Changes in α-glucosidase activities along the jejunal-ileal axis of normal rats by the α-glucosidase inhibitor miglitol. Metabolism, 59, 1442-1447 (2010)

K. Mochizuki, N. Fukaya, Y. Tanaka, M. Fuchigami, T. Goda: Treatment with the α-glucosidase inhibitor miglitol from the pre-onset stage in OLETF rats improves glycemic control and reduces the expression of inflammatory cytokine genes in peripheral leukocytes. Metabolism, in press (2011)

K. Mochizuki, Y. Misaki, R. Miyauchi, S. Takabe, M. Shimada, N. Miyoshi, Y. Ichikawa, T. Goda: Circulating interleukin-1β and interleukin-6 concentrations are closely associated with γ-glutamyltranspeptidase activity in middle-aged Japanese men without obvious cardiovascular diseases. Metabolism, in press (2010)

T. Osonoi, M. Saito, K. Mochizuki, N. Fukaya, T. Muramatsu, S. Inoue, M. Fuchigami, T. Goda: The α-glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes. Metabolism, 59, 1816-1822 (2010)

Y. Misaki, R. Miyauchi, K. Mochizuki, S. Takabe, M. Shimada, Y. Ichikawa, T. Goda: Plasma interleukin-1β concentrations are closely associated with fasting blood glucose levels in healthy and preclinical middle-aged non-overweight and overweight Japanese men. Metabolism, 59, 1465-1471 (2010)

H. Kako, Y. Kobayashi, H. Yokogoshi: Effects of n-hexanal on dopamine release in the striatum of living rats. Eur J Pharmacol., 2010 Nov 30. [Epub ahead of print] PubMed PMID: 21114973.

A. Ikari, K. Atomi, K. Kinjo, Y. Sasaki, J. Sugatani: Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells. Life Sci. 86, 766-773 (2010)

A. Yoshida, S. Maruyama, D. Fukumoto, H. Tsukada, Y. Ito, S. Yamada: Noninvasive evaluation of brain muscarinic receptor occupancy of oxybutynin, darifenacin and imidafenacin in rats by positron emission tomography. Life Sci., 25: 175-180 (2010)

K. Mochizuki, M. Igawa-Tada, S. Takase, T. Goda: Feeding rats a high fat/carbohydrate ratio diet reduces jejunal S/I activity ratio and unsialylated galactose on glycosylated chain of S-I complex. Life Sci., 86, 524-531 (2010)

S. Fujimoto, K. Mochizuki, M. Shimada, T. Hori, Y. Murayama, N. Ohashi, T. Goda: Insulin resistance induced by a high-fat diet is associated with the induction of genes related to leukocyte activation in rat peripheral leukocytes. Life Sci. 87, 679-685 (2010)

S. Fujimoto, T. Goda, K. Mochizuki: In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice. Biochem. Biophys. Res. Commu., 404, 223-227 (2011)

Y. Inamochi, K. Mochizuki, A. Osaki, T. Ishii, T. Nakayama, T. Goda: Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression. Biochem. Biophys. Res. Commu., 392, 16-21 (2010)

H. Tsutsui, T. Maeda, J.Z. Min, S. Inagaki, T. Higashi, Y. Kagawa, T. Toyo’oka: Biomarker discovery in biological specimens (plasma, hair, liver and kidney) of diabetic mice based upon metabolite profiling using ultra-performance liquid chromatography with electrospray ionization time-of-flight mass spectrometry. Clin. Chim. Acta, in press

K. Mochizuki, Y. Sato, S. Takase, T. Goda: Changes in mucosal α-glucosidase activities along the jejunal-ileal axis by an hm-HACS diet intake are associated with decreased lipogenic enzyme activity in epididymal adipose tissue. J. Agr. Food Chem., 58, 6923-6927 (2010)

M. Shimada, K. Mochizuki, T. Goda: Feeding rats dietary resistant starch reduces both the binding of ChREBP and the acetylation of histones on the Thrsp gene in the jejunum. J. Agr. Food Chem., 59, 1464-1469 (2011)

K. Kobata, K. Saito, H. Tate, A. Nashimoto, H. Okuda, I. Takemura, K. Miaykawa, M. Takahashi, K. Iwai, T. Watanabe: Long chain N-vanillyl-acylamides from Capsicum oleoresin. J. Agric. Food Chem. 58, 3627-3631 (2010)

Y. Terada, M. Narukawa, T. Watanabe: Specific hydroxyl fatty acids in royal jelly activate TRPA1. J. Agric.Food Chem. (2011) in press

A. Takeda, H. Iwaki, M. Ando, K. Itagaki, M. Suzuki, N. Oku: Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapse. Brain Res., 1323, 59-64 (2010)

A. Takeda, M. Suzuki, H. Tamano, M. Ando, N. Oku: Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components. Brain Res., 1354: 188-195 (2010)

T. Higashi, T. Ichikawa, S. Inagaki, J.Z. Min, T. Fukushima, T. Toyo’oka: Simple and practical derivatization procedure for enhanced detection of carboxylic acids in liquid chromatography-electrospray ionization-tandem mass spectrometry. J. Pharm. Biomed. Anal., 52, 809-818 (2010)

M. Shinohara, K. Uchida, S. Shimada, K. Tomioka, N. Suzuki, T. Minegishi, S. Kawahashi, Y. Yoshikawa, N. Ohashi: Novel concentration method for detection of norovirus and sapovirus from water using minute particles of amorphous calcium phosphate. J. Med. Microbiol. in press.

T. Ishii, M. Wakabayashi, T. Mori, T. Nakayama: A new method for the detection and characterization of α-lipoic acid mixed disulphides. Free Radic. Res., 44, 403-409 (2010)

H. Tamano, F. Kan, N. Oku, A. Takeda: Ameliorative effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient young mice. Brain Res. Bull., 83, 351-355 (2010)

T. Matsuda, T. Maruyama, H. Iizuka, A. Kondo, T. Tamai, K. Kurohane, Y. Imai: Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice. Food Chem. Toxicol., 48, 1704–1708 (2010)

Y. Kobayashi, H. Kako, H. Yokogoshi: Contribution of intracellular Ca2+ concentration and protein dephosphorylation to the induction of dopamine release from PC12 cells by the green odor compound hexanal. Cellular and Molecular Neurobiology, 30, 173-184 (2010)

T. Takahashi, H. Satoh, M. Takaguchi, S. Takafuji, H. Yokoyama, S. Fujii, T. Suzuki: Binding of sulfatide to recombinant hemagglutinin of influenza A virus produced by a baculovirus protein expression system. J. Biochem. 147, 459-462 (2010)

M. Takaguchi, T. Takahashi, C. Hosokawa, H. Ueyama, K. Fukushima, T. Hayakawa, K. Itoh, K. Ikeda, T. Suzuki: A single amino acid mutation at position 170 of human parainfluenza virus type 1 fusion glycoprotein induces obvious syncytium formation and caspase-3-dependent cell death. J. Biochem. 149, 191-202 (2011)

S. Misaka, S. Uchida, H. Imai, N. Inui, S. Nishio, K. Ohashi, H. Watanabe, S. Yamada: Pharmacokinetics and pharmacodynamics of low doses of midazolam administered intravenously and orally to healthy volunteers. Clin. Exp. Pharmacol. Physiol., 37: 290-295 (2010)

S. Piyaviriyakul, K. Shimizu, T. Asakawa, T. Kan, P. SIRIPONG, N. Oku: Anti-angiogenic activity and intracellular distribution of epigallalocatechin-3-gallate analogs. Biol. Pharm. Bull., 34, 396-400 (2011)

T. Tanikawa, K. Kurohane, Y. Imai: Regulatory effect of lysophosphatidic acid on lymphocyte migration. Biol. Pharm. Bull., 33, 204–208 (2010)

T. Yamanaka, K. Tsujimura, T. Kondo, T. Matsumura, H. Ishida, M. Kiso, K. IP J. Hidari, T. Suzuki: Infectivity and pathogenicity of canine H3N8 influenza a virus in horses. Influenza Other Respi. Viruses 4, 345-351 (2010)

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