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研究活動


平成23年度


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平成23年度

S. Akai, S. Ishida, K. Hatanaka, T. Ishii, N. Harada, H. Tsukada, N. Oku: Synthesis of long-chain [18F]deoxyfluoropoly(ethylene glycol) methyl ethers and their non-invasive pharmacokinetic analysis by positron emission tomography. Mol. Pharm. 8, 302-308, 2011.

T. Asai, S. Matsushita, E. Kenjo, T. Tsuzuku, N. Yonenaga, H. Koide, K. Hatanaka, T. Dewa, M. Nango, N. Maeda, H. Kikuchi, N. Oku: Dicetyl phosphate-tetraetylenepentamine- based liposomes for systemic siRNA delivery. Bioconjug. Chem. 22, 429-435, 2011.

J. M. Barichello, S. Kizuki, T. Tagami, T. Asai, T. Ishida, H. Kikuchi, N. Oku, H. Kiwada: Agitation during lipoplex formation improves the gene knockdown effect of siRNA. Int. J. Pharm. 410, 153-160, 2011.

J. Chen, S. Yamada, Y. Hama, A. K. Shetty, T. Kobayashi, H. Oda, K. Seiki, E. Kim, T. Kimura, N. Takahashi, K. I.P.J. Hidari, T. Suzuki, Y. Suzuki, K. Sugahara: Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus. Biochem. Biophys. Res. Commun. 412(1) 136-142, 2011.

K. Fukushima, T. Takahashi, T. Masahiro, H. Ueyama, S. Ito, Y. Kurebayashi, T. Kawanishi, J.L. Mckimm-Breschkin, T. Takimoto, A. Minami, T. Suzuki: Plaque formation assay for human parainfluenza virus type 1. Biol. Pharm. Bull. 34, 996-1000, 2011.

R. Furuya, H. Kumagai, T. Miyata, H. Fukasawa, S. Isobe, N. Kinoshita, A. Hishida: High plasma pentosidine level is accompanied with cardiovascular events in hemodialysis patients. Clin. Exp. Nephrol. 16, Dec 9 2011.

Gaowa, Wuritu, D. Wu, Y. Yoshikawa, N. Ohashi, F. Kawamori1, K. Sugiyama, M. Ohtake, M. Ohashi, S. Yamamoto, T. Kitano, N. Takada, H. Kawabata: Detection and characterization of p44/msp2 transcript variants of Anaplasma phagocytophilum from naturally infected ticks and wild deer in Japan, Jpn. J. Infect. Dis. in press.

S. Haramizu, F. Kawabata, K. Ohnuki, N. Inoue, T. Watanabe, S. Yazawa, T. Fushiki: Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in mice. Biomed. Res. 32(4), 279-284, 2011.

M. Hayashi-Tsugane, M. Maekawa, Q. Qian, H. Kobayashi, S. Iida, K. Tsugane: A rice mutant displaying a heterochronically elongated internode carries a 100 kb deletion. J. Genet. Genomics 38, 123-128, 2011.

M. Hayashi-Tsugane, M. Maekawa, H. Kobayashi, S. Iida, K. Tsugane: Examination of transpositional activity of nDart1 at different stages of rice development. Genes Genet. Syst. 86, 215-219, 2011.

T. Higashi, M. Suzuki, J. Hanai, S. Inagaki, J. Z. Min, K. Shimada, T. Toyo’oka: A specific LC/ESI-MS/MS method for determination of 25-hydroxyvitamin D3 in neonatal dried blood spots containing a potential interfering metabolite, 3-epi-25-hydroxyvitamin D3. J. Sep. Sci. 34, 725-732, 2011.

T. Higashi, T. Ichikawa, C. Shimizu, S. Nagai, S. Inagaki, J. Z. Min, H. Chiba, S. Ikegawa, T. Toyo’oka: Stable isotope-dilution liquid chromatography/tandem mass spectrometry method for determination of thyroxine in saliva. J. Chromatogr. B. 879, 1013-1017, 2011.

Y. Higuchi, K. Sage-Ono, R. Sasaki, N. Ohtsuki, A. Hoshino, S. Iida, H. Kamada, M. Ono: Constitutive expression of the GIGANTEA ortholog affects circadian rhythms and suppresses one-shot induction of flowering in Pharbitis nil, a typical short-day plant. Plant Cell Physiol. 52, 638-650, 2011.

M. Hiroi, T. Harada, F. Kawamori, N. Takahashi, T. Kanda, K. Sugiyama, T. Masuda, Y. Yoshikawa, N. Ohashi: A survey of β-lactamase-producing Escherichia coli in farm animals and raw retail meat in Shizuoka prefecture, Japan. Jpn. J. Infect. Dis. 64, 153-155, 2011.

Y. Hoshino, H. Koide, K. Furuya , W.W. Haberaecker, S.H. Lee, T. Kodama, H. Kanawaza, N. Oku, K.J. Shea: The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo. Proc. Natl. Acad. Sci. USA, 109, 33-38, 2012.

A. Ikari, A. Sanada, H. Sawada, C. Okude, C. Tonegawa, J. Sugatani: Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells. Biochim. Biophys. Acta. 1808, 1502-1508, 2011.

A. Ikari, A. Takiguchi, K. Atomi, J. Sugatani: Epidermal growth factor increases clathrin-dependent endocytosis and degradation of claudin-2 protein in MDCK II cells. J. Cell. Physiol. 226, 2448-2456, 2011.

A. Ikari, A. Takiguchi, K. Atomi, T. Sato, J. Sugatani: Decrease in claudin-2 expression enhances cell migration in renal epithelial Madin-Darby canine kidney cells. J. Cell. Physiol. 226, 1471-1478, 2011.

A. Ikari, H. Sawada, A. Sanada, C. Tonegawa, Y. Yamazaki, J. Sugatani: Magnesium deficiency suppresses cell cycle progression mediated by increase in transcriptional activity of p21Cip1 and p27Kip1 in renal epithelial NRK-52E cells. J. Cell. Biochem. 112, 3563-3572, 2011.

A. Ikari, T. Sato, A. Takiguchi, K. Atomi, Y. Yamazaki, J. Sugatani: Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells. Life Sci. 88, 628-633, 2011.

M. Imai, T. Watanabe, M. Hatta, S-C Das, M. Ozawa, K. Shinya, G. Zhong, A. Hanson, H. Katsura, S. Watanabe, C. Li, E. Kawakami, S. Yamada, M. Kiso, Y. Suzuki, E-A Maher, G. Neumann, Y. Kawaoka: Experimental adaptation of an influenza H5 haemagglutinin confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets. Nature, in press.

S. Inagaki, H. Hirashima, S. Taniguchi, T. Higashi, J. Z, Min, R. Kikura-Hanajiri, Y. Goda, T. Toyo’oka: Rapid enantiomeric separation and simultaneous determination of phenethylamines by ultra high-performance liquid chromatography with fluorescence and mass spectrometric detection: application to the analysis of illicit drugs distributed in the Japanese market and biological samples. Drug Test. Anal. in press.

S. Inoue, K. Mochizuki, T. Goda: Jejunal induction of SI and SGLT1 genes in rats by high-starch/low-fat diet is associated with histone acetylation and binding of GCN5 on the genes. J. Nutr. Sci. Vitaminol., 57, 162-169, 2011.

T. Ishii, Y. Ichikawa, K. Minoda, K. Kusaka, S. Ito, Y. Suzuki, M. Akagawa, K. Mochizuki, T. Goda, T. Nakayama: Human serum albumin as an antioxidant in the oxidation of (-)-epigallocatechin gallate: participation of reversible covalent binding for interaction and stabilization. Biosci. Biotechnol. Biochem., 75, 100-106, 2011.

K. Ito, S. Ito, T. Shimamura, S. Weyand, Y. Kawarasaki, T. Misaka, K. Abe, T. Kobayashi, A.D. Cameron, S. Iwata: Crystal structure of glucansucrase from dental caries pathogen Streptococcus mutans. J. Mol. Biol. 408, 177-186, 2011.

Y. Iwasaki, Y. Tamura, K. Inayoshi, M. Narukawa, K. Kobata, H. Chiba, E. Muraki, N. Tsunoda, T. Watanabe: Effect of monoacylglycerol on diet-induced obesity in mice. Biosci. Biotechnol. Biochem. 75(5), 904-909, 2011.

Y. Johzuka-Hisatomi, H. Noguchi, S. Iida: The molecular basis of incomplete dominance at the A locus of CHS-D in the common morning glory, Ipomoea purpurea. J. Plant Res. 124, 299-304, 2011.

T. Kanehira, Y. Nakamura, K. Nakamura, K. Horie, N. Horie, K. Furugori, Y. Sauchi, H. Yokogoshi: Relieving occupational fatigue by consumption of a beverage containing γ–amino butyric acid. J. Nutr. Sci. Vitaminol. 57, 9-15, 2011.

Y. Kato, M. Onishi, K. Haraguchi, S. Ikushiro, C. Ota, N. Koga, T. Endo, S. Yamada, M. Degawa: A possible mechanism for 2,2',4,4',5,5'-hexa- chlorobiphenyl-mediated decrease in serum thyroxine level in mice. Toxicol. Appl. Pharmacol. 254, 48-55, 2011.

K. Kimata, M. Yamaguchi, Y. Saito, H. Hata, K. Miyake, T. Yamane, Y. Nakagawa, A. Yano, K. Ito, Y. Kawarasaki: High cell-density expression system: A novel method for extracellular production of "difficult-to-express" proteins. J. Biosci. Bioeng. 113, 154-159, 2012.

K. Kobata, M. Mimura, M. Sugawara, T. Watanabe: Synthesis of stable isotope-labeled precursors for the biosyntheses of capsaicinoids, capsinoids, and capsiconinoids. Biosci. Biotechnol. Biochem. 75(8), 1611-1614, 2011.

A. Kobayashi, H. Yokoyama, J. Kataoka, T. Ishida, H. Kuno, S. Sugai, H. Sakakibara, K. Shimoi: Effects of spaced feeding on gene expression of hepatic transaminase and gluconeogenic enzymes in rats. J. Toxicol. Sci. 36(3), 325-37, 2011.

C. Kobayashi, K. Kurohane, Y. Imai: High dose dietary pyridoxine induces T-helper type 1 polarization and decreases contact hypersensitivity response to fluorescein isothiocyanate in mice. Biol. Pharm. Bull. in press.

H. Koide, T. Asai, K. Furuya, T. Tsuzuku, H. Kato, T. Dewa, M. Nango, N. Maeda, N. Oku: Inhibition of Akt(ser473) Phosphorylation and Rapamycin-Resistant Cell Growth by Knockdown of Mammalian Target of Rapamycin with Small Interfering RNA in Vascular Endothelial Growth Factor Receptor-1-Targeting Vector. Biol. Pharm. Bull. 34, 602-608, 2011.

T. Kojima, N. Nagao, D. Ando, T. Ojima, Y. Kawarasaki, I. Kobayashi, M. Nakajima, H. Nakano: Emulsion culture: A miniaturized library screening system based on micro-droplets in an emulsified medium. J. Biosci. Bioeng.112, 299-303, 2011.

M. Kojima, T. Ashino, T. Yoshida, Y. Iwakura, M. Degawa: Interleukin-1 controls the constitutive expression of the Cyp7a1 gene by regulating the expression of Cyp7a1 transcriptional regulators in the mouse liver. Biol. Pharm. Bull. 34, 1644-1647, 2011.

YL. Lai, S. Aoyama, M. Ohata, N. Otsuka, H. Shiokawa, S. Tomono, Y. Fujiwara, H. Kanazawa, N. Miyoshi, H. Ohshima: Dysregulation of dimethylargininedimethylaminohydrolase/asymmetricdimethylarginine pathway in rat type II diabetic nephropathy. J.Clin.Biochem.Nutr. in press.

YL. Lai, S. Tomono, N. Miyoshi, H. Ohshima: Inhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases. J. Clin. Biochem. Nutr. 50, 84-89, 2012.

R. Mabuchi, A. Kurita, N. Miyoshi, A. Yokoyama, T. Furuta, T. Goda, Y. Suwa, T. Kan, T. Amagai, H. Ohshima: Analysis of -ethyllysine in human plasma proteins by gas chromatography- negative ion chemical ionization/mass spectrometry as a biomarker for exposure to acetaldehyde and alcohol. Alcohol. Clin. Exp. Res. in press.

S. Matsumoto, T. Asakawa, Y. Hamashima, T. Kan: A Short-step Asymmetric Synthesis of Dehydrodiconiferyl Alcohol by Means of C-H Insertion Reaction. Synlett, in press.

K. Matsumoto, T. Takeuchi, N. Yokoyama, Y. Katagiri, M. Ooshiro, S. Zakimi, Gaowa, F. Kawamori, N. Ohashi, H. Inokuma: Detection of the new Ehrlichia species closely related to Ehrlichia ewingii from Haemaphysalis longicornis in Yonaguni Island, Okinawa, Japan. J. Vet. Med. Sci., 73, 1485-1488, 2011.

J. Z. Min, H. Yano, A. Matsumoto, H-f Yu, Q. Shi, T. Higashi, S. Inagaki, T. Toyo’oka: Simultaneous determination of polyamines in human nail as 4-(N,N-dimethylaminosulfonyl)-7-fluoro- 2,1,3-benzoxadiazole derivatives by nano-flow chip LC coupled with quadrupole time-of-flight tandem mass spectrometry. Clin. Chim. Acta. 412, 98-106, 2011.

J. Z. Min, S. Hatanaka, H-f Yu, T. Higashi, S. Inagaki, T. Toyo’oka: Determination of DL-amino acids, derivatized with R(-)-4-(3-isothiocyanatopyrrolidin-1-yl)-7-(N,N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole, in nail of diabetic patients by UPLC-ESI-TOF-MS. J. Chromatogr. B 879, 3220-3228, 2011.

J. Z. Min, Y. Suzuki, Y. Tomiyasu, D. Jin, T. Higashi, Y-I Lee, T. Toyo’oka: Development of novel active acceptors possessing a positively charged structure for the transglycosylation reaction with Endo-M and their application to oligosaccharide analysis. Rapid. Commun. Mass Spectrom. 25, 2911-2922, 2011.

A. Minami, H. Shimizu, Y. Meguro, N. Shibata, H. Kanazawa, K. Ikeda, T. Suzuki: Imaging of sialidase activity in rat brain sections by a highly sensitive fluorescent histochemical method. NeuroImage, 58, 34-40, 2011.

S. Misaka, R. Nakamura, S. Uchida, K. Takeuchi, N. Takahashi, N. Inui, K. Kosuge, S. Yamada, Hiroshi Watanabe: Effect of two weeks consumption of pomegranate juice on the pharmacokinetics of single dose of midazolam: an open-labeled, randomized, single-center, two-period crossover study in healthy Japanese volunteers. Clin Therap. 33, 246-252, 2011.

K. Miyamoto, S. Higashino, K. Mochizuki, T. Goda, K. Koyama: Evaluation of weight loss in the community-dwelling elderly with dementia as assessed by eating behavior and mental status. Asia Pac. J. Clin. Nutr. 20, 9-13, 2011.

K. Mochizuki, A. Ishihara, T. Goda, K. Yamauchi: RNA polymerase II phosphorylation at serine 2 and histone H3 tri-methylation at lysine 36 are key steps for thyroid hormone receptor b gene activation by thyroid hormone in Rana catesbeiana tadpole liver. Biochem. Biophys. Res. Commu. in press.

K. Mochizuki, R. Miyauchi, Y. Misaki, Y. Ichikawa, T. Goda: Principal component 1 score calculated from metabolic syndrome diagnostic parameters is a possible marker for the development of metabolic syndrome in middle-aged Japanese men without treatment for metabolic diseases. Eur. J. Nutr., in press.

K. Mochizuki, Y. Misaki, R. Miyauchi, S. Takabe, M. Shimada, K. Kuriki, Y. Ichikawa, T. Goda: A higher rate of eating is associated with higher circulating IL-1b concentrations in Japanese men without treatment for metabolic diseases. Nutrition, in press.

K. Nemoto, S. Ito, C. Yoshida, M. Miyata, M. Kojima, M. Degawa: Hepatic expression of spermatogenic genes and their transiently remarkable downregulations in Wistar-Kyoto rats in response to lead nitrate-administration: strain-difference in the gene expression patterns. J. Toxicol. Sci, 36, 357-364, 2011.

K. Nishikawa, T. Asai, H. Shigematsu, K. Shimizu, H. Kato, Y. Asano, S. Takashima, E. Mekada, N. Oku, T. Minamino :Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer. J. Control. Release, 2011.

R. Nishino, K. Ikeda, T. Hayakawa, T. Takahashi, T. Suzuki, M. Sato: Syntheses of 2-deoxy-2, 3-didehydro-N-acetylneuraminic acid analogues modified by N-sulfonylamidino groups at the C-4 position and biological evaluation as inhibitors of human parainfluenza virus type 1. Bioorg. Med. Chem. 19, 2418-2427, 2011.

M. Ogata, M. Yano, M. Umemura, S. Murata, T., Park EY, Y. Kobayashi, T. Asai, N. Oku, N. Nakamura, I. Matsuo, T. Usui: Design and Synthesis of High-Avidity Tetravalent Glycoclusters as Probes for Sambucus sieboldiana Agglutinin and Characterization of their Binding Properties. Bioconjug Chem. 23, 97-105, 2012.

Y. Ohhara, Y. Kayashima, Y. Hayashi, S. Kobayashi, K. Yamakawa-Kobayashi: Expression of β-adrenergic-like octopamine receptors during Drosophila development. Zoolog.Sci. 29, 83-89, 2011.

S. Ohno, M. Hosokawa, A. Hoshino, Y. Kitamura, Y. Morita, K. I. Park, A. Nakashima, A. Deguchi, F. Tatsuzawa, M. Doi, S. Iida, S. Yazawa: A bHLH transcription factor, DvIVS, is involved in regulation of anthocyanin systhesis in dahlia (Dahlia variabilis) . J. Exp. Bot. 62, 5105-5116, 2011.

N. Oku, M. Yamashita, Y. Katayama, T. Urakami, K. Hatanaka, K. Shimizu, T. Asai, H. Tsukada, S. Akai, H. Kanazawa: PET imaging of brain cancer with positron emitter-labeled liposomes. Int. J. Pharm. 403, 170-177, 2011.

S. Okuyama, K. Tashiro, N-V Lam, T. Hatakeyama, T. Terashima, H. Yokogoshi: Effect of the edible mushroom Mycoleptodonoides aitchisonii on transient global ischemia-induced monoamine metabolism changes in rat cerebral cortex. J. Med. Food, 15(1), 96-99, 2012.

S. Onoue, A. Uchida, H. Takahashi, Y. Seto, Y. Kawabata, K. Ogawa, K. Yuminoki, N. Hashimoto, S. Yamada: Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability. J Pharm Sci. 100, 3793-3801, 2011.

S. Onoue, Y. Seto, M. Ochi, R. Inoue, H. Ito, T. Hatano, S. Yamada: In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts. Phytochemistry. 72, 1814-1820, 2011.

M. Pervin, N. Paeng, K. Yasui, S. Imai, M. Isemura, H. Yokogoshi, T. Nakayama: Effects of Lens culinaris agglutinin on gene expression of gluconeogenic enzymes in the mouse intestine. J. Sci. Food Agric. in press.

K. Sakai-Kato, T. Hasegawa, A. Takaoka, M. Kato, T. Toyo’oka, N. Utsunomiya-Tate, T. Kawanishi: Controlled structure and properties of silicate nanoparticle networks for incorporation of biosystem components. Nanotechnology, 22, 205702 (pp1-8), 2011.

K. Shintaku, K. Uchida, Y. Suzuki, M. Kashio, Z. Yiming, Y. Takayama, T. Fushiki, T. Watanabe, S. Yazawa, M. Tominga: Activation of TRPA1 by a non-pungent capsaicin-like compound, capsiate.Br. J. Pharmacol. in press.

Y. Suzuki, N. Miyoshi, M. Isemura: Health-promoting effects of green tea. Proc. Japan Acad. Ser B. in press.

K. Suzuki, T. Koyama, S. Yingsakmongkon, Y. Suzuki, K. Hatano, K. Matsuoka: Synthesis and biological evaluation of sialic acid derivatives containing a long hydrophobic chain at the anomeric position and their C-5 linked polymers as potent influenza virus inhibitors. Bioorganic & Medicinal Chemistry, 20, 446-454, 2012.

Y. Takanami, T. Nakayama: Evaluation of superoxide anion radicals generated from aqueous extract of particulate phase cigarette smoke by electron spin resonance using 5,5-dimethyl-1-pyrroline-N-oxide. Biosci. Biotechnol. Biochem. 75, 34-39, 2011.

A. Takeda, H. Tamano, T. Ogawa, S. Takada, M. Ando, N. Oku, M. Watanabe: Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency. Behav. Brain Res. 226, 259-264, 2012.

A. Takeda, H. Tamano, M. Suzuki, K. Sakamoto, N. Oku, H. Yokogoshi: Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response. Cell. Mol. Neurobiol. 32, 41-48, 2012.

A. Takeda, K. Itagaki, M. Ando, N. Oku: Involvement of NMDA receptor subunits in zinc-mediated modification of CA1 LTP in the developing hippocampus. J. Neurosci. Res. 90, 551-558, 2012.

A. Takeda, K. Sakamoto, H. Tamano, K. Fukura, N. Inui, S. W. Suh, S-J Won, H. Yokogoshi: Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory. Cell. Mol. Neurobiol. 31, 1079-1088, 2011.

A. Takeda, M. Suzuki, H. Tamano, S. Takada, K. Ide, N. Oku: Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress. Neurochem. Int. in press.

A. Takeda, S. Takada, M. Nakamura, M. Suzuki, H. Tamano, M. Ando, N. Oku: Transient increase in Zn2+ in hippocampal CA1 pyramidal neurons causes reversible memory deficit. PLoS One, 6, e28615, 2011.

Y. Taki, E. Hagiwara, C. Hirose, K. Shinozuka, K. Umegaki, S. Yamada: Effects of Ginkgo biloba extract on the pharmacokinetics and pharmacodynamics of tolbutamide in protein-restricted rats. J. Pharm. Pharmacol. 63, 1238-1243, 2011.

T. Tanaka, T. Ishii, D. Mizuno, T. Mori, R. Yamaji, Y. Nakamura, S. Kumazawa, T. Nakayama, M. Akagawa: (-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD-box RNA helicase p68. Free Radic. Biol. Med. 50, 1324-1335, 2011.

T. Tanikawa, K. Kurohane, Y. Imai: Regulatory Effect of Cannabinoid receptor agonist on chemokine-induced lymphocyte chemotaxis. Biol. Pharm. Bull. 34, 1090-1093, 2011.

Y. Tobisawa, T. Maruyama, T. Tanikawa, K. Nakanishi, K. Kurohane, Y. Imai: Establishment of recombinant hybrid-IgG/IgA immunoglobulin specific for Shiga toxin. Scand. J. Immunol. 76, 574-584. 2011.

K. Tokutomi, T. Tagawa, M. Korenaga, M. Chiba, T. Asai, N. Watanabe, S. Takeoka, M. Handa, Y. Ikeda, N.Oku: Decoration of fibrinogen γ-chain peptide on adenosine diphosphate-encapsulated liposomes enhances binding of the liposomes to activated platelets. Int. J. Pharm. 407, 151-157, 2011.

S. Tomono, N. Miyoshi, M. Ito, T. Higashi, H. Ohshima: A highly sensitive LC-ESI-MS/MS method for the quantification of cholesterol ozonolysis products secosterol-A and secosterol-B after derivatization with 2-hydrazino-1-methylpyridine. J. Chromatogr. B. 879, 2802-2808, 2011.

H. Tsuboi, H. Sakakibara, K. Yamakawa-Kobayashi, A. Tatsumi, T. Inamori, R. Hamamoto, A. Suzuki, K. Shimoi: Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress. J. Affect. Disorders, 134(1-3), 448-485, 2011.

K. Tsujioka, M. Ohsumi, K. Sakamoto, P. Thanapreedawat, M. Akao, M. Kim, K. Hayase, H. Yokogoshi: Effect of dietary γ–aminobutyric acid on the brain protein synthesis rate in hypophysectomized aged rats. J. Nutr. Sci. Vitaminol. 57(4), 285-291, 2011.

Y. Uekusa, M. Kamihira-Ishijima, O. Sugimoto, T. Ishii, S. Kumazawa, K. Nakamura, K. Tanji, A. Naito, T. Nakayama: Interaction of epicatechin gallate with phospholipid membranes as revealed by solid-state NMR spectroscopy. Biochim. Biophys. Acta. 1808, 1654-1660, 2011.

K. Unno, K. Fujitani, N. Takamori, F. Takabayashi, K.I. Maeda, H. Miyazaki, K. Iguchi, K. Shimoi, M. Hoshino: Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice. Free Radic. Res. 45(8), 966-974, 2011.

T. Wakimoto, H. Kondo, H. Nii, K. Kimura, Y. Egami, Y. Oka, M. Yoshida, E. Kida, Y. Ye, S. Akahoshi, T. Asakawa, K. Matsumura, H. Ishida, H. Nukaya, K. Tsuji, T. Kan, I. Abe: Furan fatty acid as an anti-inflammatory component from green-lipped mussel, Perna canaliculus. Proc. Natl. Acad. Sci. USA, 108, 17533-17537, 2011.

T. Wakimoto, K. Miyata, H. Ouchi, T. Asakawa, H. Nukaya, Y. Suwa, T. Kan: Enantioselective Total Synthesis of Aperidine. Org. Lett. 13, 2789-2791, 2011.

Y. Watanabe, M. S. Ibrahim, H. F. Ellakany, N. Kawashita, R. Mizuike, H. Hiramatsu, N. Sriwilaijaroen, T. Takagi, Y. Suzuki, K. Ikuta: Acquisition of Human-Type Receptor Binding Specificity by New H5N1 Influenza Virus Sublineages during Their Emergence in Birds in Egypt. PLoS Pathogens, 7(5), e-1002068, 2011.

S. Wichit, A. Jittmittraphap, K. I.P.J. Hidari, B. Thaisomboonsuk, S. Petmitr, S. Ubol, C. Aoki, S. Itonori, K. Morita, T. Suzuki, Y. Suzuki, W. Janpangern: Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells. Microbiol. and Immunol. 55, 135-140, 2011.

S. Yamada, K. Shinya, A. Takada, T. Ito, T. Suzuki, Y. Suzuki, Q. Le, M. Ebina, N. Kasai, H. Kida, T. Horimoto, P. Rivailler, L. Chen, R. Donis, Y. Kawaoka: Adaptation of a duck influenza A virus in quail. J. Virol. 86, 1411-1420, 2012.

S. Yamada, M. Seki, M. Ogoda, A. Fukata, M. Nakamura, Y. Ito: Selective binding of bladder muscarinic receptors in relation to the pharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder. J. Pharmacol. Exp. Ther. 336, 365-371, 2011.

H. Yamaguchi, Y. Hirakura, H. Shirai, H. Mimura, T. Toyo’oka: Quantitative evaluation of protein conformation in pharmaceuticals using cross-linking reactions coupled with LC-MS/MS analysis. J. Pharm. Biomed. Anal. 55, 574-582, 2011.

K. Yamakawa-Kobayashi, M. Natsume, S. Aoki, S. Nakano, T. Inamori, N. Kasezawa, T. Goda: The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study. BMC Med. Genet. in press.

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